Psychedelic-Assisted Therapy
Below is a list of resources that our team recommends to patients regularly.
How to change your mind by Michael Pollan
The Ketamine Papers: Science, Therapy, and Transformation by Phil Wolfson and Glen Hartelius
The Psychedelics Integration Handbook by Ryan Westrum and Jay Dufrechou
We know that most mental health disorders shorten your lifespan
Depression and shortened lifespan
Increased mortality among people with anxiety disorders: total population study
Below is some of the evidence on psychedelic-assisted therapies that treat many of these disorders.
Multiple peer-reviewed studies have demonstrated that ketamine provides rapid and impressive anti-depressant effects which persist beyond the approximately one-hour infusion. Ketamine has multiple unique mechanisms of action that work to interrupt anxiety, depression, and pain by decreasing systemic inflammation, healing the brain, and creating openness to new ways of thinking and relating to the self and others.
Conclusions: Repeated ketamine infusions have cumulative and sustained antidepressant effects. Reductions in depressive symptoms were maintained among responders through once-weekly infusions. These findings provide novel data on efficacious administration strategies for ketamine in patients with treatment-resistant depression.
Ketamine and PTSD
Conclusions: In this double-blind, placebo-controlled crossover study, a single dose of Ketamine (.5mg/kg over 40 minutes) was compared to midazolam. Authors note a significant immediate reduction in the CAPS score and frequently this reduction was maintained for over 2 weeks. The only side effects noted were transient dissociative symptoms, none of which required stopping the infusion.
Ketamine for treatment of mood disorders and suicidality: A narrative review of recent progress
Conclusions: This narrative review describes the evolution of ketamine to treat mood disorders and suicidality. We provide evidence supporting recent developments using esketamine as well as unresolved issues in the field, such as dosing and safety.
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Post-traumatic Stress Disorder
Conclusions: This randomized controlled trial provides the first evidence of efficacy of repeated ketamine infusions in reducing symptom severity in individuals with chronic PTSD. Further studies are warranted to understand ketamine’s full potential as a treatment for chronic PTSD.
Ketamine route of administration
There are several ways to give ketamine. There are pros and cons to intranasal, intramuscular and intravenous. This study shows that Intramuscular ketamine in the dose of 0.25 mg/kg is as effective and safe as 0.5 mg/kg given either I.M. or I.V., substantially alleviating depressive symptoms within a few hours and sustained for 3 days.
Currently, at this time, Manifest Health is offering intramuscular. However, in the future, all routes will be available.
Ketamine and other psychedelic assisted therapy
Wild Health Podcast
Psychedelic Therapy For Alcohol Misuse and PTSD in Special Forces Veterans
Ketamine for anxiety, depression, PTSD, pain, and much more with Ben Askins, PA
Can Ketamine Therapy + Self Worth Training Improve Depression? with Dr. Kristin Dawson and Ben Askins
Exploring The 3 Types of Psychedelic Experiences
Podcast Episode on Brainspotting and Sports Performance: Thad Frye, LCSW and Dr. Tom McCoy
Podcast Episode on Brainspotting: Thad Frye, LCSW and Ben Askins, PA
The Psychedelic Podcast by Third Wave
The Journey to Conscious Health: Getting the Most Out of Ketamine Therapy with Remi Drozd, DO
Heal, Grow, Love, Transcend: Ketamine & the Future of Mental Healthcare with Sam Zand, DO